Lei Zhao Selected Research

Emodin (Archin)

1/2020	Effect of Emodin on Coxsackievirus B3m-Mediated Encephalitis in Hand, Foot, and Mouth Disease by Inhibiting Toll-Like Receptor 3 Pathway In Vitro and In Vivo.
1/2020	Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway.
1/2019	Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile.
12/2016	Preliminary study on Emodin alleviating alpha-naphthylisothiocyanate-induced intrahepatic cholestasis by regulation of liver farnesoid X receptor pathway.
11/2015	Emodin induces apoptosis of human breast cancer cells by modulating the expression of apoptosis-related genes.
10/2013	The combined effect of survivin-targeted shRNA and emodin on the proliferation and invasion of ovarian cancer cells.
3/2009	[Therapeutic effects of emodin on acute cholestatic hepatitis and mechanism thereof: experiment with rats].
8/2008	Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway.

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Lei Zhao Research Topics

Disease

248	Neoplasms (Cancer) 12/2022 - 10/2006
100	Inflammation (Inflammations) 09/2022 - 09/2002
55	Infections 03/2022 - 04/2007
53	Neoplasm Metastasis (Metastasis) 10/2022 - 12/2004
40	Fibrosis (Cirrhosis) 01/2022 - 02/2013
31	Breast Neoplasms (Breast Cancer) 05/2022 - 06/2007
29	Hepatocellular Carcinoma (Hepatoma) 06/2022 - 12/2004
29	Stomach Neoplasms (Stomach Cancer) 08/2021 - 03/2009
28	Carcinogenesis 09/2022 - 10/2009
27	Esophageal Squamous Cell Carcinoma 03/2022 - 08/2012
25	Insulin Resistance 01/2022 - 01/2009
24	Atherosclerosis 01/2022 - 09/2002
23	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 09/2004
22	COVID-19 12/2022 - 01/2020
22	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 07/2022 - 03/2009
22	Obesity 05/2022 - 01/2009
22	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 01/2012
18	Type 2 Diabetes Mellitus (MODY) 12/2022 - 12/2005
18	Non-alcoholic Fatty Liver Disease 01/2022 - 01/2009
17	Carcinoma (Carcinomatosis) 05/2022 - 03/2009
17	Heart Failure 12/2021 - 01/2009
17	Necrosis 12/2021 - 03/2006
16	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 12/2004
16	Sepsis (Septicemia) 01/2022 - 05/2006
15	Hypoxia (Hypoxemia) 07/2022 - 12/2011
15	Stroke (Strokes) 01/2022 - 09/2004
15	Hemorrhage 01/2022 - 01/2007
15	Brain Ischemia (Cerebral Ischemia) 01/2022 - 06/2008
14	Ischemia 01/2022 - 06/2008
14	Pancreatic Neoplasms (Pancreatic Cancer) 07/2021 - 12/2009
14	Liver Cirrhosis (Hepatic Cirrhosis) 01/2020 - 10/2009
13	Reperfusion Injury 01/2020 - 06/2008
12	Myocardial Infarction 01/2022 - 09/2004
11	Periodontitis 03/2022 - 02/2008
11	Lung Neoplasms (Lung Cancer) 02/2022 - 03/2009
11	Colonic Neoplasms (Colon Cancer) 01/2022 - 10/2009
11	Atrial Fibrillation 01/2022 - 01/2019
11	Lymphoma (Lymphomas) 01/2022 - 04/2008
11	Leukemia 11/2021 - 07/2010
11	Body Weight (Weight, Body) 06/2021 - 08/2011
11	Ischemic Stroke 03/2021 - 01/2015
11	Esophageal Neoplasms (Esophageal Cancer) 01/2021 - 12/2013
10	Adenocarcinoma of Lung 12/2022 - 02/2015
10	Virus Diseases (Viral Diseases) 12/2022 - 06/2014
10	Cognitive Dysfunction 02/2022 - 05/2010
10	B-Cell Lymphoma (Lymphoma, B Cell) 01/2022 - 04/2008
10	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2021 - 04/2009
9	Hyperuricemia 03/2022 - 01/2019
9	Pain (Aches) 03/2022 - 11/2006
9	Glioma (Gliomas) 02/2022 - 11/2011
9	Osteosarcoma (Osteogenic Sarcoma) 01/2022 - 08/2015
9	Infarction (Infarctions) 01/2022 - 06/2008
9	Squamous Cell Carcinoma of Head and Neck 03/2021 - 01/2019

Drug/Important Bio-Agent (IBA)

124	Proteins (Proteins, Gene)FDA Link 09/2022 - 01/2002
74	Biomarkers (Surrogate Marker)IBA 09/2022 - 10/2007
45	Messenger RNA (mRNA)IBA 12/2022 - 09/2002
43	Pharmaceutical PreparationsIBA 05/2022 - 07/2006
34	MicroRNAs (MicroRNA)IBA 01/2022 - 05/2010
30	CytokinesIBA 07/2022 - 09/2002
29	Glucose (Dextrose)FDA LinkGeneric 06/2022 - 12/2005
28	Biological ProductsIBA 01/2022 - 10/2007
26	LipidsIBA 01/2022 - 09/2004
25	Long Noncoding RNAIBA 01/2022 - 11/2015
24	EnzymesIBA 06/2022 - 07/2004
22	Interleukin-6 (Interleukin 6)IBA 04/2022 - 05/2006
21	LipopolysaccharidesIBA 01/2022 - 12/2005
20	Therapeutic UsesIBA 05/2022 - 03/2009
19	Phosphotransferases (Kinase)IBA 12/2020 - 07/2010
18	CholesterolIBA 10/2021 - 01/2009
17	Antiviral Agents (Antivirals)IBA 05/2022 - 11/2010
16	LigandsIBA 10/2022 - 07/2008
16	Peptides (Polypeptides)IBA 01/2022 - 09/2002
16	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2009
15	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2022 - 05/2006
15	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 03/2010
14	Immune Checkpoint InhibitorsIBA 10/2022 - 01/2020
14	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 12/2006
13	Fatty Acids (Saturated Fatty Acids)IBA 06/2022 - 01/2014
13	CateninsIBA 01/2022 - 12/2018
13	InterleukinsIBA 12/2021 - 08/2007
13	C-Reactive ProteinIBA 01/2021 - 02/2007
13	corilaginIBA 01/2020 - 07/2008
12	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2011
12	Monoclonal AntibodiesIBA 01/2018 - 06/2007
11	Cisplatin (Platino)FDA LinkGeneric 03/2022 - 03/2010
11	Insulin (Novolin)FDA Link 12/2021 - 12/2005
11	Amyloid (Amyloid Fibrils)IBA 01/2020 - 05/2010
10	Doxorubicin (Adriamycin)FDA LinkGeneric 07/2022 - 01/2014
10	AntibodiesIBA 03/2021 - 04/2008
10	Small Interfering RNA (siRNA)IBA 01/2021 - 01/2012
9	Neuroprotective AgentsIBA 02/2022 - 06/2008
9	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2021 - 01/2013
9	AntigensIBA 01/2021 - 07/2008

Therapy/Procedure

98	Therapeutics 12/2022 - 12/2004
44	Drug Therapy (Chemotherapy) 07/2022 - 11/2006
19	Radiotherapy 07/2022 - 01/2013
16	Immunotherapy 07/2022 - 05/2016
12	Neoadjuvant Therapy 06/2022 - 08/2015
12	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2021 - 10/2013
10	Chemoradiotherapy 03/2022 - 01/2014